Subgenual Cingulate–Amygdala Functional Disconnection and Vulnerability to Melancholic Depression
نویسندگان
چکیده
منابع مشابه
Guilt-Selective Functional Disconnection of Anterior Temporal and Subgenual Cortices in Major Depressive Disorder
Context: Proneness to overgeneralization of self-blame is a core part of cognitive vulnerability to major depressive disorder (MDD) and remains dormant after remission of symptoms. Current neuroanatomical models of MDD, however, assume general increases of negative emotions and are unable to explain biases toward emotions entailing self-blame (eg, guilt) relative to those associated with blamin...
متن کاملSevere melancholic depression is more vulnerable than non-melancholic depression to minor precipitating life events.
BACKGROUND The present study examines the moderating role of global depression severity on the relation of melancholic versus non-melancholic depression to severe and non-severe levels of stress. METHOD A community sample of 50 women with unipolar major depressive disorder, of which 54% met Research Diagnostic Criteria for melancholic depression, were interviewed regarding stressful life even...
متن کاملIdentifying melancholic depression biomarker using whole-brain functional connectivity
[Abstract] Importance Melancholia, with biological homogeneity, has been a key to understand critical features of major depressive disorder (MDD). Previous biomarker studies have focused on severe treatment-resistant depression with recurrent episodes. However, for effective treatment selection, it is also very important to focus on majority of depression like melancholia, from general clinic o...
متن کاملA magnetic resonance imaging study of hippocampal, amygdala and subgenual prefrontal cortex volumes in major depression subtypes: melancholic versus psychotic depression.
BACKGROUND Volumetric studies examining brain structure in depression subtypes are limited and inconclusive. The aim of the current study was to compare the volumes of brain regions previously implicated in depression among patients with melancholic major depressive disorder (MDD), patients with psychotic MDD and normal controls. METHODS Twenty two patients with melancholic MDD, 17 with psych...
متن کاملFemale vulnerability to depression
Evidence from several sources indicates that there is an increased risk of neuroses among women. This evidence derives from psychiatric in-patient samples (Cochrane & Stopes-Roe, 1981), from general practice patients (Shepherd et al. 1966) and, most important, from community studies (Bebbington et al. 1981). Weissman & Klerman (1977) have reviewed the evidence and argue that social factors cont...
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ژورنال
عنوان ژورنال: Neuropsychopharmacology
سال: 2016
ISSN: 0893-133X,1740-634X
DOI: 10.1038/npp.2016.8